#$%^&*AU2020204341A120200716.pdf#####: Interwoven NRPortbl DCCSXD 20370812_I.DOCX-26/06/2020 ABSTRACT The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; (1) wherein R1, R3-R, X 2 and X 3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.WO 2018/073788 PCT/1B2017/056515 113 Figure 1. XRPCoflexampni:e I hdrateorm