Seok Hee Park,Youn Sook Lee,Yoe Sik Bae,Seong-Jin Kim
申请号：
US13730423
公开号：
US09227997B2
申请日:
2012.12.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed is a pharmaceutical composition comprising a Smad6-derived peptide as an active ingredient. Having ability to specifically bind to Pellino-1, the Smad6-derived peptide is effectively useful in the treatment of the sepsis mediated by excessively activated TLR. The peptide effectively reduces the expression of inflammatory cytokines, protects cells from sepsis-induced apoptosis, and exhibits high bacterial clearance in animal models of sepsis.
