THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
Wayne Marasco,Jianhua Sui,Quan Zhu,Thomas Kupper
申请号：
US15236279
公开号：
US10584172B2
申请日:
2016.08.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
