A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HCl (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.本發明係關於一種製備噴霧乾燥萬古黴素(vancomycin)之方法及調配物。在各種不同實施例中,該調配物包括下列一或多者:萬古黴素鹽酸鹽(10-20%)及PEG(0-5%)、甘露醇(0-5%)、乙醇(0-10%)及檸檬酸鹽緩衝液。噴霧乾燥萬古黴素具有良好的復原時間及水含量。100...噴霧乾燥系統102...乾燥氣體104...預濾器106...風扇108...加熱器110...無菌氣體過濾器111...入口氣體溫度計112...霧化器113...無菌過濾製程114...乾燥室115...槽與混合器摻合系統116...噴霧118...旋流分離器/噴霧乾燥器旋流分離器119...出口120...濾筒過濾裝置121...出口122...第二過濾器124...第三過濾器125...出口氣體溫度計200...收集容器
