The present invention relates to a liquid formulation containing botulinum toxin, stabilizing agent, and local anesthetic, and preparation method therefor.A formulation containing a botulinum toxin, stabilizing agent, and local anesthetic according to the present invention is a liquid formulation which is easily stored and distributed, and it exhibited a remarkable effect on the stabilization of botulinum toxin with local anesthetic under suitable conditions according to the temperature and pH of the human body. Thus, it is expected that the formulation of the present invention will greatly contribute to the safe and convenient medical use of botulinum toxin.本發明是關於一種含有肉毒桿菌毒素、穩定劑以及局部麻醉劑的液體調配物及用於其的製備方法。根據本發明的含有肉毒桿菌毒素、穩定劑以及局部麻醉劑的調配物為容易儲存及分散的液體調配物,且其在根據人體的溫度及pH值的適合條件下在具有局部麻醉劑的肉毒桿菌毒素的穩定化上呈現顯著效應。因此,預期本發明的調配物將非常有助於肉毒桿菌毒素安全且適宜的醫療用途。