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Compounds that inhibit the activity of the viral rna polymerase
专利权人:
BIOCRYST PHARMACEUTICALS; INC.
发明人:
YARLAGADDA S. BABU,PRAVIN L. KOTIAN
申请号:
ARP130101229
公开号:
AR090699A1
申请日:
2013.04.16
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Pharmaceutical compounds containing a formula compound (1) are also provided.And a method for treating viral infection using formula compound (1). Claim 1: compound (1) represented by formula,Or salt with acceptable efficacy, marked as: 1,LZ,L3,L830808,L830909,And l8310,a. Each is C (r83044) 832222-o -;R830404,a. H or C 832131 for each occurrence;R1,R2,R3...Each is from h, carbamate, carbamate, acid, r18304; (OC (o) -,Phosphorus and aminophosphorus; R1 and R2,Take them with you, or Lars and Larstaken together, they are selected from the group consisting of carbonyl, thiocarbonyl, phosphoryl and C₁₋₆phosphoryl alkyl; R⁴,R83099,R8310A,Everyone is from h, acid, phospholipid, asphalt, r1830404;; OC (o) -,Keywords calcium carbamate; r8311es h; or r8310a;R8311th,Combined with the nitrogen attached to them, it represents - n = CR * 83044; R2;R830404,independently for each occurrence, it is selected from the group consisting of H, C₁₋₆-alkyl,Arilo, heterosexual, aralquilo and heterosexual; 83044 and R2,Each compound is selected from the group consisting of H, alkyl, amino, arilo, Silurus meridionalis, aralquilo and Silurus meridionalis, provided that the compound (1) represented by the formula is not the compound (2) of the formula.También se proporcionan composiciones farmacéuticas que comprenden compuestos de la fórmula (1), así como métodos para tratar infecciones virales usando compuestos de la fórmula (1). Reivindicación 1: Un compuesto representado por la fórmula (1), o su sal farmacéuticamente aceptable, caracterizado porque: L¹, L², L³, L⁴, L⁵, y L⁶, cada uno independientemente, son un enlace o un conector de -C(R⁰)₂-O-; R⁰, independientemente para cada aparición, es H o alquilo C₁₋₆; R¹, R², y R³, cada uno independientemente, se seleccionan del grupo formado por H, aminoacilo, aminotionilo, acilo, R¹⁰OC(O)-, fosforilo y aminofosforilo; R¹ y R², tomados juntos, o R² y R³, tomados juntos, se seleccionan del grupo formado por carbonilo, tiocarbonilo, fosforilo y alq
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