The present disclosure relates to a cannabis-infused product comprising acannabinoid profileincluding one or more cannabinoid, a first composition for controlling onsetof the cannabinoidprofile and a second composition for controlling offset of the cannabinoidprofile in a subjecthaving used the cannabis-infused product, wherein the second composition has adelayed onsetcompared to that one of the first composition. The present disclosure alsorelates to methods ofmanufacture and of using same.