Zhiqiang An;Louis Jerry Fabri;Manuel Baca;William R. Strohl;Andrew Donald Nash;Dennis Zaller
发明人:
Andrew Donald Nash,Manuel Baca,Louis Jerry Fabri,Dennis Zaller,William R. Strohl,Zhiqiang An
申请号：
US12445753
公开号：
US08613925B2
申请日:
2007.10.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Antibody antagonists of human interleukin-13 receptor alpha 1 which bind to hIL-13Rα1 through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13 are disclosed herein. These antibodies have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing hIL-13Rα1-mediated activities are also disclosed.
