ИНСЕРМ (ЭНСТИТЮ НАСЬОНАЛЬ ДЕ ЛЯ САНТЭ Э ДЕ ЛЯ РЕШЕРШ МЕДИКАЛЬ) (FR)
发明人:
ШАББЕР Кристьян (FR),ВЕНАЙ Фредерик (FR)
申请号：
RU2011151834/15
公开号：
RU2011151834A
申请日:
2010.05.20
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. Antagonist of serotonin 5-HT receptors for use in the treatment of vestibular disorders with damage. 2. The serotonin 5-HT receptor antagonist according to claim 1, wherein said serotonin 5-HT receptor antagonist is selected from the group consisting of small organic molecules, antibodies and aptamers. The serotonin 5-HT receptor antagonist according to claim 2, wherein said serotonin 5-HT receptor antagonist is selected from the group consisting of ondansetron, palonosetron, tropisetron, lerisetron, alosetron, granisetron, dolasetron, bernesetron, ramosetron, azasetron, and azasetron, Zakoprid and Cylansetron. 4. The serotonin 5-HT receptor antagonist according to claim 3, wherein the serotonin 5-HT receptor antagonist is ondansetron. The serotonin 5-HT receptor antagonist according to claim 2, wherein said serotonin 5-HT receptor antagonist is a compound of formula (I): wherein R is a C-cycloalkyl- (C) -alkyl group or a C-alkynyl group； and one of the groups represented by R, R and R represents a hydrogen atom or a C-alkyl, C-cycloalkyl, C-alkenyl or phenyl- (C) -alkyl group, and each of the other two groups, which may be the same or different represented by a hydrogen atom or a C-alkyl group； and its physiologically acceptable salts and solvates. 6. An inhibitor of gene expression of serotonin 5-HT receptors for use in the treatment of vestibular lesions with lesions. 7. The serotonin 5-HT receptor gene expression inhibitor according to claim 6, wherein the serotonin 5-HT receptor gene expression inhibitor is selected from the group consisting of antisense RNA or DNA molecules, small inhibitor RNAs (siRNAs) and ribozymes. �1. Антагонист серотониновых 5-НТ-рецепторов для применения при лечении вестибулярных нарушений с повреждениями.2. Антагонист серотониновых 5-НТ-рецепторов по п.1, в котором данный антагонист серотониновых 5-НТ-рецепторов выбран из группы, состоящей из малых органических молекул, антител и аптамеров.3. Антагонист серотониновых 5-НТ-рецепторов
