Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies

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专利权人:

Trion Pharma GmbH

发明人:

Lindhofer, Horst

申请号：

AU2007216472

公开号：

AU2007216472B2

申请日:

2007.02.15

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases. It has been found that said trifunctional bispecific antibodies are binding to tumor-associated antigens selected from Her2/neu, CD20, EpCAM, G250, proteoglycans, GD3, GD2, MHC II, EGF-R and CEA, wherein said tumor-associated antigens are expressed on said tumor cell with a low to medium expression level only.

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