AKT activitys inhibitor农业专利-农业专业知识服务系统

发明人:: M．J．凯利,M．J．凱利,M．E．莱顿,M．E．萊頓,M．E．利括里,Y．奥吉诺,Y．奧吉諾,Y．奥诺扎基,Y．奧諾扎基,P．E．桑德森,J．王,M.J.凯利,M.J.凱利,M.E.莱顿,M.E.萊頓,M.E.利括里,Y.奥吉诺,Y.奧吉諾,Y.奥诺扎基,Y.奧諾扎基,P.E.桑德森,J.王

摘要：: The present invention provides inhibit the active substituted naphthyridine compounds of Akt. Particularly, disclosed compound selectively inhibits one or two Akt isodynamic enzymes. It needs compound described in the patient for the treatment of cancer the present invention also provides the composition for including this inhibitory compound and by giving and inhibits the active methods of Akt.本發明提供了抑制Akt活性的取代的二氮雜萘化合物。特別地，所公開的化合物選擇性地抑制一種或兩種Akt同工酶。本發明還提供了包括這種抑制性化合物的組合物以及通過給予需要治療癌症的患者所述化合物來抑制Akt活性的方法。