Gregory D. Jay,Benjamin D. Sullivan,Tannin Avery Schmidt,Khaled Elsaid,Edward R. Truitt,Roman Krawetz,Joanna Szmydynger-Chodobska,Adam Chodobska,Jawed Fareed
申请号：
US15546192
公开号：
US20180015141A1
申请日:
2016.01.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are methods of using PRG4 glycoprotein, also known as lubricin, to reduce, inhibit, or down-regulate pro-inflammatory pathways in patients at risk of or suffering from an inflammatory response or allergy symptom through CD44 antagonization, regulating pro-inflammatory cytokine production, inhibiting NF-κB translocation and/or facilitating removal of inflammation-inducing cellular or matrix debris or allergens.
