ФРАЙ Дэвид Шэнк (US),ЛИНДЕМАНН Кристофер М. (US),ПРЕЙ Майкл (US),БЛУМ Кори Джей (US),КРЕЙГ Кристофер Донован (US),ДЮБОЗ Девон Бревар (US),ГОТШИ Джеф (US),СМИТИ Дэн (US)
申请号：
RU2014119283/15
公开号：
RU2014119283A
申请日:
2012.10.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A solid dispersion comprising N4- (4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) -N6- (4,4-dimethyl-4 5-dihydro-oxazol-2-yl) quinazoline-4,6-diamine and polimer.2 dispersion. The solid dispersion of claim 1 comprising amorphous N4- (4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl) -N6- (4,4-dimethyl -4,5-dihydro-oxazol-2-yl) quinazoline-4,6-diamin.3. The solid dispersion according to claim 1 or 2, characterized in that said dispersion polymer is selected from vinyl polymers and copolymers, PVP-VA, polyvinyl alcohols, polyvinyl alcohol copolymers and polyvinyl acetate, PVP, acrylate and methacrylate copolymers, methyl acrylic acid and methyl methacrylate copolymers polyethylene and polyvinyl alcohol, block copolymers of polyoxypropylene-polyoxyethylene graft copolymer consisting of polyethylene glycol, and polyvinyl polivinilkaprolaktama, cellulosic polymers Such as GPMTSA, HPMC, HPC, methyl cellulose, hydroxyethylmethylcellulose, hydroxyethylcellulose, hydroxyethyl acetate and hydroxyethyl ethylcellulose, GPMTSAS, hydroxypropylmethylcellulose phthalate HPMCP, carboxymethyl CMEC, cellulose acetate phthalate, TSAF, cellulose acetate succinate CAC, hydroxypropylmethylcellulose acetate phthalate GPMTSAF, cellulose acetate trimellitate ACPC, hydroxypropylmethylcellulose acetate trimellitate GPMTSAT and carboxymethyl cellulose acetate butyrate KMTSAB, and the podobnyh.4. The solid dispersion according to claim 1 or 2, characterized in that the dispersion polymer selected from a copolymer of polyvinylpyrrolidone / vinyl acetate copolymer, methyl acrylic acid / methyl methacrylate, hydroxypropylmethylcellulose phthalate, and cellulose acetate phthalate and hydraulic1. Твердая дисперсия, содержащая N4-(4-([1,2,4]триазоло[1,5-a]пиридин-7-илокси)-3-метилфенил)-N6-(4,4-диметил-4,5-дигидрооксазол-2-ил)хиназолин-4,6-диамин и дисперсионный полимер.2. Твердая дисперсия по п.1, содержащая аморфный N4-(4-([1,2,4]триазоло[1,5-a]пиридин-7-илокси)-3-м
