PROBLEM TO BE SOLVED: To provide production methods of granulated materials which contain a pharmaceutical at a high content and can be tableted into a tablet with sufficient hardness, particularly production methods of granulated materials which can solve the problem by minimizing the amount of an additive used even if a medicine is hardly flowable.SOLUTION: The present invention provides a wet granulation method using a solution in which one part of a pharmaceutical is dissolved or suspended in water or a water-containing solvent, as a binding solution. The invention provides a method of producing a granulated material, for example, when producing a granulated material containing a variety of pharmaceuticals, comprising uniformly mixing a fluidizer and 50 to 100 mass% to the total weight of pharmaceutical powders relatively poorly soluble to water or water-containing solvent, to fluidize and spraying as a binding solution a solution in which relatively easy soluble pharmaceutical powders and remaining poorly soluble pharmaceutical powders are dissolved or suspended in water or a water-containing solvent.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】医薬を高含有率で含有し、且つ十分な硬度を有する錠剤に打錠し得る造粒物の製造方法を提供すること、特に、医薬が難流動性である場合でも、添加剤の使用量を極力抑えて前記課題を解決し得る造粒物の製造方法を提供すること。【解決手段】医薬の一部を水又は水含有溶媒に溶解又は懸濁させた液を結合液として用いて湿式造粒する方法を提供する。たとえば、複数種の医薬を含有する造粒物を製造する場合、水又は水含有溶媒に対し相対的に難溶性の医薬粉末の総重量の50から100質量%と流動化剤とを均一に混合し、流動化させ、ここに、相対的に易溶性の医薬粉末及び残りの難溶性医薬の粉末とを水又は水含有溶媒に溶解又は懸濁させた液を結合液として噴霧して造粒物を製造する方法を提供する。【選択図】なし
