Cleavage inhibitors of transforming growth factor beta type I receptor and uses thereof in cancer therapy

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专利权人:

Marene Inga-Britt Landstrom

发明人:

Marene Inga-Britt Landstrom,Yabing Mu,Reshma Sundar,Noopur Thakur,Shyam Kumar Gudey,Maria Ekman,Carl-Henrik Heldin

申请号：

US14004490

公开号：

US09296818B2

申请日:

2012.03.13

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Disclosed herein are methods to inhibit cleavage of a type I receptor of transforming growth factor beta (TβRI) and reduce cancer cell invasiveness/metastasis, and agents and pharmaceutical compositions for use in these methods. Also disclosed herein are methods for identifying agents that inhibit cleavage of TβRI and methods for diagnosing and/or prognosing cancer based on nuclear localization of a intracellular domain of TβRI, which is a product of TβRI cleavage.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/