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VIRION-LIKE DELIVERY PARTICLES FOR SELF-REPLICATING RNA MOLECULES
专利权人:
发明人:
申请号:
EP11741348.4
公开号:
EP2590676B1
申请日:
2011.07.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
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