Muhammed Majeed,Kalyanam Nagabhushanam,Lakshmi Mundkur
申请号：
US16015503
公开号：
US20180369166A1
申请日:
2018.06.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed is the use of garcinol for the therapeutic management of ER stress. More specifically, the invention discloses the ability of garcinol in decreasing ER stress and mitigating toxicity by reducing protein aggregation and decreasing expression of ER stress markers SXBP, GRP78 and ATF4, which indicates translational attenuation and recovery in hyperglycemia, paracetamol, alcohol, thapsigargin and high fat diet induced toxicity models.
