FERENC MAKRA,LEYI GONG,LUBICA RAPTOVA,WYLIE SOLANG PALMER,XIAOCHUN HAN
申请号:
BR112012003059
公开号:
BR112012003059A2
申请日:
2010.08.06
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein p, q, Y', r, R1, R2, X, X1, X2, X3, and X4 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.