The present application provides a vaccine composition comprising: bacteria engineered to express at least one N-glycan of Campylobacter,such as C. jejuni for example,or an N-glycan derivative thereof on its cell surface； and one or more of a physiologically acceptable diluent, excipient, adjuvant or carrier. The bacteria is Escherichia coli, Salmonella or any suitable bacteria that offers sufficient expression and improved immunogenic response. The vaccine composition can be formulated for administration to animals, such as poultry, including chickens.
