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Indonesian Derivatives as Anti-Dengue Virus Replication Inhibitors
专利权人:
JANSSEN PHARMACEUTICALS, INC.;KATHOLIEKE UNIVERSITEIT LEUVEN
发明人:
申请号:
ARP180101352
公开号:
AR111820A1
申请日:
2018.05.22
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
This application covers alternative indilin derivatives for the prevention or treatment of dengue virus infection with these compounds, as well as their use as medicines, preferably for the treatment of dengue virus infection. Treatment or prevention of viral dengue fever infection. 2. The present document also deals with the synthesis or compound preparations of these compounds, as well as the synthesis or preparation used as medicines.It is best used to prevent or treat viral dengue fever infection. It also involves the preparation of compounds. Claim 1: A formula compound (1),Including its chemical isomerization stereo form, where A is a compound of formula (2) or (3);R1 is chlorine, R 2 is hydrogen, R3 is hydrogen, A is formula compound (2).R83088 is sulfur pentafluoride, R83099 is hydrogen, Z is carbon, R8310 is hydrogen, or R1 is chlorine, R 2 is hydrogen, R3 is hydrogen, this is the compound of formula (2).R830808e is trifluoromethyl, R83099 is hydrogen, Z is carbon, R8310 is methyl, or R1 is chlorine, R 2 is hydrogen, R3 is hydrogen, A is formula compound (2),R830808e is sulfur trifluoride, R83099a is fluorine, Z is carbon, R8310a is hydrogen, or R1 is chlorine, R 2 is hydrogen, R3 is hydrogen, A is formula compound (2),R83088ES trifluorometoxi, R83099ES is hydrogen, Z is carbon, R8310s is methyl, or R1 is chlorine, R 2 is hydrogen, R3 is hydrogen, A is formula compound (2),R83088ES trifluorometoxi, R83099ES is fluorine, Z is carbon, R8310s is hydrogen, or R1 is fluorine, R 2 is methy, R3 is hydrogen, A is formula compound (2),R83088ES trifluorometoxi, R83099ES is hydrogen, Z is carbon, R8310s is hydrogen, or R1 is chlorine, R 2 is hydrogen, R3 is deuterium, A is formula (2),R83088ES trifluorometoxi, R83099ES is hydrogen, Z is carbon, R8310s is hydrogen; or R1 is chlorine, R2 ES-och 8322; Ch8322OH, R3 is hydrogen, A is formula compound (2),R83088ES trifluorometoxi, R83099ES is hydrogen, Z is carbon, R8310s is hydrogen, or R1 is chlorine, R 2 is hydrogen, R3
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