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6-(1-甲基-1H-吡唑-4-基)-2-{3-[5-(2-嗎啉-4-基-乙氧基)-嘧啶-2-基]-苄基}-2H-噠嗪-3-酮磷酸二氫鹽的多晶型物及其製備方法
专利权人:
MERCK PATENT GMBH
发明人:
BECKER, AXEL,KUEHN, CLEMENS,SAAL, CHRISTOPH,SCHADT, OLIVER,DORSCH, DIETER,KRIEGBAUM, EVA,STIEBER, FRANK,DONINI, CRISTINA
申请号:
HK12105184.1
公开号:
HK1164837B
申请日:
2012.05.28
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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