A compound according to Formula I: ** Formula ** wherein: R1 is hydrogen, hydroxy, halo, trifluoroalkyl, alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, aralkyl, carboxyl, amido, amino, alkoxy, sulfanyl , sulfenyl, sulfonyl, or ether； R2 is hydrogen, halo, hydroxy, trifluoromethyl, alkoxy, alkyl, alkenyl, alkynyl, carbocyclic, alkylcarbocyclic, alkylheterocyclic, heterocyclic, or -R9-OR10, where R9 is a covalent bond, or alkylene, and R10 is hydrogen, alkyl, C-amido, or acyl； or R2 together with R3 and the atoms to which they are attached form a carbocyclic ring with 5 to 7 ring members or a heterocyclic ring having 4 to 8 ring members with at least one hetero atom selected from oxygen or nitrogen； R3 is hydrogen, hydroxy, halo, trifluoroalkyl, alkyl, alkoxy, sulfanyl, or -R11-OR12, where R11 is a covalent bond or alkylene, and R12 is alkyl, C-amido, or acyl； or R3 together with R2 and the atoms to which they are attached form a carbocyclic ring with 5 to 7 ring members or a heterocyclic ring having 4 to 8 ring members with at least one hetero atom selected from oxygen or nitrogen； or R3 is absent when Y is = N-； R4 is hydrogen, hydroxy, alkyl, arylalkoxy, carboxyl, -R13 -OR14 or -R13 -R15； and where R13 is a covalent bond or alkylene, and R14 is hydrogen, C-amido, or acyl, or R15 is N-amido, -POR16R17, -SO2R18 or sulfonamido, and where R16, R17, R18 are independently alkoxy； R5 is hydrogen, hydroxy, alkyl, arylalkoxy, alkenyl, alkynyl, aryl, or aralkyl； R6 is hydrogen, hydroxy, sulfanyl, alkyl, alkenyl, alkynyl, aryl, arylalkyl, alkoxy, aryloxy, arylalkoxy, or a heterocyclic ring having 4 to 8 ring members with at least one heteroatom selected from oxygen or nitrogen； R7 is hydrogen, hydroxy, arylalkoxy, alkyl, acyl, carboxyl, or is absent； R8 is hydrogen, hydroxy, or arylalkoxy； X1 is -CHR19- or -CR19 =, and wherein R19 is selected from hydrogen, halo, alkyl, alkenyl, or alkynyl； or X1 together with X2 form a carbocyclic ring having 3 to 7 ring members；
