PROBLEM TO BE SOLVED: To provide an agent for increasing the concentration in skin, which comprises a physiologically-active ingredient, and mass production of which can be achieved inexpensively and industrially.SOLUTION: The agent for increasing the concentration in skin, comprising a physiologically-active ingredient, is configured so as to uses, as an active ingredient: monoglycerin-fatty acid ester having an HLB of 9 to 12 diglycerin-fatty acid ester having an HLB of 8 to 11 or polyglycerin-fatty acid ester having an HLB of 11 to 14.COPYRIGHT: (C)2012,JPO&INPIT【課題】安価で工業的に大量生産が可能な、生理活性成分の皮膚中濃度増加剤を提供する。【解決手段】HLBが9~12のモノグリセリン脂肪酸エステル、HLBが8~11のジグリセリン脂肪酸エステル又はHLBが11~14のポリグリセリン脂肪酸エステルを有効成分とする、生理活性成分の皮膚中濃度増加剤。【選択図】なし