Rossi, Edmund,McBride, William,Chang, Chien-hsing,Goldenberg, David
申请号：
AU2008316741
公开号：
AU2008316741B9
申请日:
2008.10.24
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention concerns methods and compositions for forming PEGylatedcomplexes of defined stoichiometry and structure. In preferred embodiments,the PEGylated complex is formed using dock-and-lock technology, by attachingan effector moiety to a DDD sequence and attaching a PEG moiety to an AD sequenceand allowing the DDD sequence to bind to the AD sequence in a 2: 1 stoichiometry,to form PEGylated complexes with two effector moieties and one PEG moiety. Inalternative embodiments, the effector moiety may be attached to the AD sequenceand the PEG to the DDD sequence to form PEGylated complexes with two PEG moietiesand one effector moiety. In more preferred embodiments, the effector moietymay comprise any peptide or protein of physiologic or therapeutic activity.The PEGylated complexes exhibit a significantly slower rate of clearance wheninjected into a subject and are of use for treatment of a wide variety of diseases.
