САСС Филип М. (US),НИКОЛЭЙДЕС Николас (US),ГРАССО Луиджи (US),РУТЬЕ Эрик (US),ГУ Вэй (US),ЯНГ Джейсон (US),ЯО Цзюнь (US)
申请号：
RU2013122843/10
公开号：
RU2013122843A
申请日:
2011.10.19
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A monoclonal antibody which specifically binds to folate receptor alpha (FRA), wherein the monoclonal antibody comprises a heavy chain amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 5 with or without C-terminal lysine, and further comprising an amino acid sequence of the light chain selected from: an amino acid sequence that is 99% identical to the amino acid sequence of SEQ ID NO: 2 the amino acid sequence of SEQ ID NO: 6 or an amino acid sequence of SEQ ID NO: 7, and wherein the monoclonal antibody has an altered antibody-dependent cellular cytotoxicity (ADCC) ADCC compared with the monoclonal antibody when it is received in the standard conditions kultivirovaniya.2. A monoclonal antibody according to claim. 1, where ADCC povyshena.3. A monoclonal antibody according to claim. 1, where ADCC ponizhena.4. A monoclonal antibody according to claim. 2, which has an increased internalization rate compared to the rate of internalization of monoclonal antibodies produced in standard conditions kultivirovaniya.5. A monoclonal antibody which specifically binds to folate receptor alpha (FRA), wherein the monoclonal antibody comprises the amino acid sequence of heavy chain SEQ ID NO: 1 or SEQ ID NO: 5, with or without C-terminal lysine, and further comprising an amino acid sequence of the light chain selected from: the amino acid sequence that is 99% identical to the amino acid sequence of SEQ ID NO: 2 the amino acid sequence of SEQ ID NO: 6 or an amino acid sequence of SEQ ID NO: 7, and wherein the monoclonal antibody has an altered internalization rate compared to the rate of internalization m1. Моноклональное антитело, которое специфически связывается с фолатным рецептором альфа (FRA), где моноклональное антитело содержит аминокислотную последовательность тяжелой цепи SEQ ID NO:1 или SEQ ID NO:5 с или без С-концевого лизина, и дополнительно содержит аминокислотную последовательность легкой цепи, выбранную из: аминокислотной последовательности, которая на 99% идентична
