Discloses anti-TWEAK-receptor antibodies or antigen binding fragment thereof, which can inhibit or prevent the growth of a solid tumour expressing SEQ ID NO:2 comprising: (i) Heavy chain CDR1 encoded by SEQ ID NO:120 with allowed amino acid substitution (ii) Heavy chain CDR2 encoded by SEQ ID NO:121 with allowed amino acid substitution (iii) Heavy chain CDR3 encoded by SEQ ID NO:122 with allowed amino acid substitution (iv) Light chain CDR1 encoded by SEQ ID NO:127 with allowed amino acid substitution (v) Light chain CDR2 encoded by SEQ ID NO:128 with allowed amino acid substitution (vi) Light chain CDR3 encoded by SEQ ID NO:129 with allowed amino acid substitution Further disclosed are anti-TWEAK-receptor antibodies or antigen binding fragment comprising a VH region comprising either SEQ ID NOs: 3, 5, 7 or 9 and VL region comprising either SEQ ID NOs: 4, 6, 8 or 10. Further disclosed are said antibodies which may be linked to an effector moiety and which may be used in the manufacture of a medicament for treatment of cancers.
