THE MEDICAL COLLEGE OF WISCONSIN, INC.;WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人:
Joseph T. Barbieri,Chen Chen,Amanda Przedpelski,Eric A. Johnson,Sabine Pellett
申请号：
US15509371
公开号：
US20170281737A1
申请日:
2015.09.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides a universal delivery platform of functional, heterologous compounds to specific cells using toxins modified to include a heterologous compound. In one embodiment, the toxin is an AB5 toxin. In one embodiment, the AB5 toxin is a heat-labile enterotoxin from E. coli (LT), including LTI, LTII, LTIIa, LTIIb, LTIIc and other recombinant forms of LT. Methods of use are also provided.
