This disclosure describes techniques for controlling spectral aggressors in a sensing device that uses a low power sleep mode to manage the power consumed by the device. In some examples, the techniques for controlling spectral aggressors may include configuring one or more of an algorithm processing rate for a processor, a buffering rate for the processor, a sampling rate for an analog-to-digital converter, an execution unit processing rate for the processor, and an algorithm subdivision factor for the processor such that spectral interference caused by a sleep cycle rate of the processor occurs outside of one or more target frequency bands of a sampled signal. The techniques of this disclosure may be used to reduce noise in a sensing system that uses a low power sleep mode to manage the power consumed by the device.