FIELD: veterinary medicine.SUBSTANCE: method of manufacturing a vaccine against streptococcal bovine diseases includes cultivation in a nutrient medium of microorganisms Str. agalactiae 346 (serogroup B), Str. zooepidemicus 2082 (serogroup C), Ent. Faecalis (serogroup D), inactivation of microorganisms and addition of an aluminum hydroxide adjuvant. At the same time, microorganisms are taken in the vaccine in equal volumes at initial concentrations of 17.5-25.5 billion m.t./cm, cultivation of cultures of strains of streptococci is carried out at oxidation-reduction potential of a culture liquid -200÷-150 mV, until the end of the cultivation process, pOin the culture liquid at a level of 15-25% of the saturation with air oxygen, the pH of the culture liquid is adjusted at the level of 6.8-7.2, and the fractional glucose supply is carried out in doses up to a concentration of 0.05-0.2% when the streptococcal growth is limited by glucose, Inactivation of streptococcal cultures is carried out with formaldehyde a
