In Vivo and Ex Vivo Expansion of Hematopoietic Stem Cells With a Targeted Combination of Clinically Tested, FDA Approved Drugs

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专利权人:

The Trustees of the University of Pennsylvania

发明人:

Peter S. Klein,Jian Huang

申请号：

US15274601

公开号：

US20170065640A1

申请日:

2016.09.23

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/