A vessel seal for reversibly sealing a body lumen comprises a support structure moveable between an insertion and deployed configuration, wherein a diameter of the support structure in the deployed configuration is greater than in the insertion configuration, and is substantially corresponding to an inner diameter of a lumen. A compressible vessel seal is coupled to the support structure so that, when in the deployed configuration, the vessel seal expands to occlude the lumen. A method of controlling flow through a body lumen, comprises the steps of inserting into a lumen a vessel seal assembly including a support structure and a compressible vessel seal coupled thereto and moving the support structure to a deployed configuration in which the vessel seal expands to occlude the lumen, wherein a diameter of a support structure in the deployed configuration is greater than in the insertion configuration and substantially corresponds to an inner diameter of the lumen.
