#$%^&*AU2017254892A120180201.pdf#####ABSTRACT Novel molecules termed STING (Stimulator of Interferon Genes) which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a subject. STING compositions are useful for the treatment of an immune-related disorder, including treating and preventing infection by modulating immunity.