UNIVERSITY OF MARYLAND, BALTIMORE;Gliknik Inc.;UNIVERSITY OF MARYLAND; BALTIMORE
发明人:
STROME, Scott E.,SCHULZE, Dan H.,BLOCK, David S.,OLSEN, Henrik
申请号：
ES08769936
公开号：
ES2565834T3
申请日:
2008.05.30
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound comprising two or more multimerized units, wherein each of said units comprises a multimerization region and a region comprising at least one Fc domain that is capable of binding to an Fcγ receptor, in which each of said units comprises two dimerized monomers, wherein each of said monomers comprises a multimerization region monomer and a region comprising at least one Fc domain monomer, where the dimerization of the two monomers forms a multimerization region and a region that It comprises at least one Fc domain that is capable of binding to an Fcγ receptor, in which the multimerization regions of the two or more units are multimerized to form the compound, and wherein the compound is capable of binding to a first Fcγ receptor. through a first Fc domain and to a second Fcγ receptor through a second Fc domain, in which the multimerization region is selected from the group consisting of a b isagra of IgG2, a CH2 domain of IgE, a leucine zipper, an isoleucine zipper and a zinc finger, and in which each of the regions comprising at least one Fc domain that is capable of binding to an Fcγ receptor it comprises a hinge of IgG1, a CH2 domain of IgG1 and a CH3 domain of IgG1.Un compuesto que comprende dos o mas unidades multimerizadas, en el que cada una de dichas unidades comprende una region de multimerizacion y una region que comprende al menos un dominio Fc que es capaz de unirse a un receptor Fcγ, en el que cada una de dichas unidades comprende dos monomeros dimerizados, en donde cada uno de dichos monomeros comprende un monomero de region de multimerizacion y una region que comprende al menos un monomero de dominio Fc, en donde la dimerizacion de los dos monomeros forma una region de multimerizacion y una region que comprende al menos un dominio Fc que es capaz de unirse a un receptor Fcγ, en el que las regiones de multimerizacion de las dos o mas unidades se multimerizan para formar el compuesto, y en donde el compuesto es capaz de unirse a un primer recep
