KIM, JIN SUN,KIM, DAE JIN,LEE, SANG HYUN,JUNG, SUNG YOUB,KWON, SE CHANG
申请号：
PE0005942015
公开号：
PE14202015A1
申请日:
2013.11.06
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Referring to a composition for preventing or treating diabetes or diabetic complications, DIABESITY, comprising an Analogue of oxintomodulina as active principle. The Invention also relates to a method for Treating Obesity or diabetes, diabetic complications, which comprises administering an effective amount of a pharmaceutically oxintomodulina Analogue of a subject.The Analogue of oxintomodulina has a High Ability to activate glp-1 receptor and the Glucagon Receptor in comparison with Native oxintomodulina. The Analogue of oxintomodulina induces beta Cell Expansion and increases insulin secretion, thereby reducing Blood glucose levels are increased due to a Diet high in fat and high in calories.The Analogue of oxintomodulina induces Reductions in body weight and intake of diet to improve insulin sensitivity and allow the blood glucose levels, which are not controlled due to insulin resistance are maintained at normal levels.Thus, the oxintomodulina Analogue can be effectively used to prevent or treat Diabetes and related diseasesReferida a una composicion para prevenir o tratar diabetes, diabesidad o complicaciones diabeticas, que comprende un analogo de oxintomodulina como principio activo. La invencion tambien se refiere a un procedimiento para tratar diabetes, obesidad o complicaciones diabeticas, que comprende administrar una cantidad farmaceuticamente efectiva de un analogo de oxintomodulina a un sujeto. El analogo de oxintomodulina tiene una alta capacidad de activar el receptor GLP-1 y el receptor glucagon, en comparacion con la oxintomodulina nativa. El analogo de oxintomodulina induce la expansion de celulas beta y aumenta la secrecion de insulina, reduciendo de ese modo los niveles de glucosa en sangre que se incrementaron debido a una dieta elevada en grasas y elevada en calorias. El analogo de oxintomodulina induce reducciones en el peso corporal e ingesta de dieta para mejorar la sensibilidad a la insulina y permitir que los niveles de glucosa en sangr
