The present invention provides a method for inhibiting NF-κB activity in a subject, the method comprising providing an agent capable of inducing expression of annexin 1, whereby said agent induces expression of annexin 1 and whereby said induced expression of annexin 1 inhibits NF-κB activity. Also provided are annexin 1 mimetics capable of binding to NF-κB and pharmaceutical compositions of such inducing and mimetic agents.
