Compositions and methods for inhibiting fungal growth by administering AR-12 to a host infected with a fungus such as Histoplasma capsulatum, Aspergillusfumigatus, and Trichophyton rubrum, Paecilomyces, Rhizopus, Fusarium, Scedosporium, Lomentospora, Apophysomyces, Coccidioides, Blastomyces, non-albicans Candida, and Pneumocytis are provided. Aspects described herein provide methods and composition for inhibiting fungal infections in a host. As described herein, AR-12 can be administered to fungus or fungal cells to inhibit or reduce the growth of fungus. In another aspect, AR-12 can be administered to a mammal infected with a fungus to inhibit or reduce the growth of the fungus or to treat a condition caused by the fungus. The route of administration for AR-12 can be any suitable route used for current antifungal treatments (e.g., topical, oral, ophthalmic, intravenous, intranasal, inhalation, transdermal).Se proporcionan composiciones y métodos para inhibir el crecimiento micótico al administrar AR-12 a un hospedador infectado con un hongo tal como Hostoplasma capsulum, Aspergillus fumigatus y Trichophyton rubrum, Paecilomyces, Rhizopus, Fusarium, Scedosporium, Lomentospora, Apophysomyces, Coccidoides, Blstomyces, Candida que no es Candida albicans, y Pneumocytis.
