HEISER, ULRICH U,SOMMER, ROBERT R,RAMSBECK, DANIEL D,MEYER, ANTJE A,HOFFMANN, TORSTEN T,BOEHME, LIVIA L,DEMUTH, HANS-ULRICH H-U,.海澤,.佐默,.拉姆斯貝克,.邁耶,.赫夫曼,.伯厄勒,.德穆特
申请号：
HK13102485.3
公开号：
HK1175135B
申请日:
2013.02.27
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
