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PROCÉDÉ DE FABRICATION DE FIBRES DE HYALURONATE À L'AIDE DE FILAGE PAR FUSION, ET FIBRES DE HYALURONATE FABRIQUÉES PAR CE DERNIER
专利权人:
LTD.;JINWOO BIO CO.,LTD.;(주)진우바이오;JINWOO BIO CO.
发明人:
KWEON, Dong Keon,권동건,PARK, Seung Hyeon,박승현
申请号:
KRKR2016/009748
公开号:
WO2017/039335A1
申请日:
2016.09.01
申请国别(地区):
KR
年份:
2017
代理人:
摘要:
The present invention relates to hyaluronate fibers and, more specifically, to: hyaluronate fibers which can be used as a surgical suture, a filler for cosmetic surgery, a lifting thread, scaffold for tissue engineering, and the like; and a manufacturing method therefor. The method for manufacturing hyaluronate fibers by using melt spinning, comprises the steps of: (a) adjusting the water content of hyaluronate, having a weight-average molecular weight of 500-3,000 kDa, to 5-20%; (b) putting the hyaluronate of which the water content is adjusted in a melt spinning device, heating the same to 150-200°C, and performing high pressure spinning so as to manufacture hyaluronate fibers; and (c) dipping the hyaluronate fibers in an ethanol aqueous solution and hardening the surface thereof. The hyaluronate fibers of the present invention are manufactured with hyaluronate as the primary component, thereby having excellent safety and biocompatibility, and do not cause contamination by microorganisms, as opposed to conventional liquid hydrogel products, and are easy to manage and use, thereby being usable as various forms of preparations for repairing tissues. In addition, the hyaluronate fibers of the present invention are solid-form products, thereby having a very small volume in comparison to the concentration of the hyaluronate, such that the therapeutic effect thereof can be maximized by minimizing a patient's pain and discomfort during administration to the body.La présente invention concerne des fibres de hyaluronate, et, plus spécifiquement : des fibres de hyaluronate qui peuvent être utilisées comme suture chirurgicale, charge de remplissage pour chirurgie cosmétique, fil de levage, échafaudage pour génie tissulaire, et analogues ; et leur procédé de fabrication. Le procédé de fabrication de fibres de hyaluronate à l'aide de filage par fusion comprend les étapes suivantes consistant : (a) à régler la teneur en eau de hyaluronate, ayant une masse moléculaire moyenne en
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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