The Board of Trustees of the Leland Stanford Junior University
发明人:
Karl Deisseroth,Edward S. Boyden
申请号：
US16039176
公开号：
US20180328944A1
申请日:
2018.07.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
