Trustees of Boston University;The Regents of the University of California
发明人:
SHIRIHAI, Orian,GRINSTAFF, Mark,ZENG, Jialiu
申请号:
AU2019210313
公开号:
AU2019210313A1
申请日:
2019.01.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.