The present invention provides fully human antibodies that bind to either toxin A or toxin B of Clostridium difficile, or to both toxin A and toxin B, compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for neutralizing the toxins from C. difficile, thus providing a means of treating the disease and symptoms associated with a C. difficile infection, including the treatment of diarrhea, or pseudomembranous colitis caused by C. difficile. The antibodies may also prevent the severity and/or duration of the primary disease, or may prevent the number, duration, and/or the severity of recurrences, or relapses of the disease attributed to the presence of C. difficile. The antibodies of the invention may also be useful for diagnosis of an infection by C. difficile.本發明提供結合艱難梭狀芽孢桿菌之毒素A或毒素B,或結合至毒素A與毒素B兩者的完全人類抗體;包含該等抗體的組成物及使用方法。本發明抗體可用於中和艱難梭狀芽孢桿菌的毒素,因而提供治療與艱難梭狀芽孢桿菌有關之疾病和症狀(包括治療由艱難梭狀芽孢桿菌引起之腹瀉或偽膜性大腸炎)的方法。該等抗體可防止首發病的嚴重性及/或持續時間,或可預防因為存在艱難梭狀芽孢桿菌所致疾病的再發或復發次數、持續時間,及/或嚴重性。本發明抗體亦可用於診斷因為艱難梭狀芽孢桿菌所致的感染。
