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Liquid Factor VIII Formulations
专利权人:
发明人:
Christian Rischel,Hans Holmegaard Soerensen,Michael Bech Jensen,Thomas Bjerg
申请号:
US14420564
公开号:
US20160000884A1
申请日:
2013.08.13
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention is directed to a liquid, aqueous formulation of coagulation Factor VIII, comprising a Factor VIII molecule, a calcium salt in a concentration of more than 10 mM, and a saccharide and/or polyol in a concentration of at least 100 mM, wherein the formulation has a pH from 5.5-7.5. The invention furthermore provides a method for optimising a liquid formulation of coagulation Factor VIII, the method comprising the steps of: (i) Providing one or more liquid formulations comprising Factor VIII to be tested (ii) Adding a protein denaturant to said liquid formulations, and incubating the resulting solutions for a predetermined period of time (iii) Analysing the incubated solutions of (ii) for the presence of dissociated Factor VIII and (iv) Selecting one or more formulation(s) having a desired low level of dissociated Factor VIII.
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