The invention provides a method of inhibiting angiogenesis in an individual, the method c omprising administering to the individual an agent that inhibits the interaction between CLEC14A and MMNR2. The inhibitor may be an antibody, a polypeptide, a peptide, a p olynucleotide, a peptidomimetic, anatural product, a carbohydrate, an aptamer or a small molecule