SPINO, MICHAEL,HUI, ANITA,YANG, CIHUA,KABIR, MOHAMMED, N
申请号：
NZ58860208
公开号：
NZ588602A
申请日:
2008.04.25
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
The disclosure relates to an oral pharmaceutical liquid formulation comprising deferiprone and a taste masking composition, said taste masking composition comprising an effective amount of a sweetener (such as sucralose) per litre of liquid formulation, an effective amount of a thickening and suspension aid, (for example hydroxyethylcellulose), per litre of liquid formulation, an effective amount of a humectant (such as glycerin) per litre of liquid formulation, and an effective amount of at least one flavoring agent, wherein a final form of said oral liquid pharmaceutical formulation has a substantially non-bitter and palatable taste. A palatable liquid pharmaceutical formulation specifically comprises: about 50-200 grams of deferiprone per litre of the formulation, about 15 grams of sucralose per litre of the formulation, about 500 grams of glycerin per litre of the formulation, about 1 gram of hydroxyethylcellulose per litre of the formulation, about 59 grams of concentrated hydrochloric acid per litre of the formulation, about 0040 grams of FD&C Yellow No.6 per litre of the formulation, about 2 grams of artificial cherry flavour per litre of the formulation, about 0.10 grams of peppermint oil per litre of the formulation and a sufficient amount of purified water to yield 1 litre of the formulation.
