TIMMERMAN, PETER,PUIJK, WOUTER CORNELIS,HACKENG, TILMAN MATHIAS,GRIFFIOEN, ARJAN WILLEM
申请号：
NZ59448110
公开号：
NZ594481A
申请日:
2010.02.05
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Provided is a protein mimic adapted to induce an immune response, wherein said immune response is cross-reactive to a member of the cystine-knot growth factor superfamily, said protein mimic having the motif X0-C1-X1-C2-X2-C3-X3-C4-X4-C5-X5-C6-X6, wherein C1 to C6 are cysteine residues which form a cystine-knot structure in which C1 is linked to C4, C2 is linked to C5 and C3 is linked to C6, and wherein X0 and X6 represent, independently from each other, an amino acid sequence with a length of 0 to 10 amino acids, X2 represents an amino acid sequence with a length of 2 to 24 amino acid residues with at least 70% sequence identity to the amino acid sequence located between C2 and C3 of a member of the cystine-knot growth factor superfamily, X5 represents an amino acid sequence with a length of 1 amino acid residue, X1 represents an amino acid sequence with a length of 15 to 50 amino acids with at least 70% sequence identity to the amino acid sequence located between C1 and C2 of a member of the cystine-knot growth factor superfamily, X3 represents an amino acid sequence with a length of 3 to 36 amino acids with at least 70% sequence identity to the amino acid sequence located between C3 and C4 of a member of the cystine-knot growth factor superfamily, and X4 represents an amino acid sequence with a length of 15 to 50 amino acids with at least 70% sequence identity to the amino acid sequence located between C4 and C5 of a member of the cystine-knot growth factor superfamily, and wherein at least one cysteine in any of the sequences represented by X1, X2, X3, X4 and X6 is replaced by another amino acid residue.
