DUMONT JENNIFER A.,LOW SUSAN,BITONTI ALAN J.,PIERCE GLENN,LUK ALVIN,JIANG HAIYAN,MCKINNEY BYRON,OTTMER MATT,SOMMER JURG,NUGENT KAREN,LI LIAN,PETERS ROBERT
申请号：
NZ61943812
公开号：
NZ619438A
申请日:
2012.07.06
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a pharmaceutical composition comprising: (i) a chimeric polypeptide, which comprises a Factor VIII (FVIII) portion and a second portion； and (ii) at least one pharmaceutically acceptable excipient, wherein 15% to about 25% of the FVIII portion of the chimeric polypeptide comprises single chain FVIII and about 75% to about 85% of the FVIII portion of the chimeric polypeptide comprises processed FVIII, and wherein the composition is lyophilised. Also disclosed is use of the pharmaceutical composition of anyone of claims 1 to 24 in the manufacture of a medicament for preventing, decreasing or treating a bleeding episode in a human.
