Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.本文提供使用胎盤細胞(例如本文中所描述之胎盤幹細胞及胎盤多潛能細胞(PDAC))及該等胎盤細胞之群體治療患有循環系統疾病或病症之個體的方法。本發明亦提供使用該等細胞或包含該等細胞之細胞群體使血管新生的方法。