Stelic Institute of Regenerative Medicine; Stelic Institute & Co.
发明人:
Hiroyuki YONEYAMA,Jun KOYAMA,Masato FUJII
申请号：
US14704333
公开号：
US20150290238A1
申请日:
2015.05.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
As a result of dedicated studies, the present inventors succeeded in discovering, for the first time, that fibrogenesis could be suppressed at the physiological tissue level by inhibiting sulfation at position 4 or 6 of GalNAc, which is a sugar that constitutes sugar chains. Furthermore, the present inventors conducted studies using various disease model animals, and as a result, successfully demonstrated that inhibitors of sulfation at position 4 or 6 of GalNAc had therapeutic effects on diseases caused by tissue fibrogenesis (tissue fibrogenic disorders).
