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Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
专利权人:
Mark A. Gallop
发明人:
Mark A. Gallop,Jia-Ning Xiang,Fenmei Yao,Laxminarayan Bhat,Cindy X. Zhou
申请号:
US12480518
公开号:
US08143437B2
申请日:
2009.06.08
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
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