PERRETT STEPHEN,COHEN FREDRIC JAY,VENKATESH GOPI M
申请号：
NZ59940110
公开号：
NZ599401A
申请日:
2010.09.30
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is An orally disintegrating solid pharmaceutical composition comprising from about 0.01mg to about 20 mg of a topically administrable corticosteroid selected from the group consisting of budesonide, fluticasone, flunisolide, ciclesonide, mometasone, beclomethasone, and salts, solvates and esters thereof and at least one disintegrant, wherein the composition has no significant systemic glucocorticoid or mineralocorticoid activity after oral administration, wherein the solid pharmaceutical composition disintegrates within 60 seconds when tested using the USP <701> Disintegration Test, and wherein upon administration the corticosteroid is deposited topically in the upper gastrointestinal tract. The disintegrants of the disclosure include: crospovidone, sodium starch glycolate, cross-linked sodium carboxymethylcellulose, calcium silicate, and low substituted hydroxypropyl cellulose.
